Annual report pursuant to Section 13 and 15(d)

STOCKHOLDERS' DEFICIT (Details Narrative)

v3.24.2
STOCKHOLDERS' DEFICIT (Details Narrative) - USD ($)
1 Months Ended 12 Months Ended
Jan. 27, 2023
Jan. 12, 2023
Jun. 15, 2020
Dec. 29, 2017
Dec. 31, 2023
Nov. 30, 2023
Jan. 31, 2023
Sep. 30, 2022
Jun. 30, 2022
Dec. 31, 2023
Dec. 31, 2022
Apr. 30, 2023
Dec. 31, 2021
Sep. 29, 2021
Feb. 09, 2021
Dec. 31, 2020
Dec. 31, 2018
Class Of Warrant Or Right [Line Items]                                  
Convertible notes principal amount         $ 29,946,000         $ 29,946,000 $ 27,562,000            
Change in fair value of warrant derivative liabilities                   1,195,000 1,304,000            
Warrants granted, term   5 years           5 years                  
Warrants granted to purchase common stock   7,500,000           500,000                  
Warrant derivative liability         65,000         65,000 70,000            
Change in fair value of derivative liabilities                   $ 1,200,000              
Weighted average remaining contractual life (years), outstanding                   2 years 1 month 6 days              
Share-based compensation                   $ 1,262,000 16,000            
Research and development                   1,189,000 1,725,000            
Common stock issued for services                     119,000            
Warrant excercise price   $ 4.5           $ 2.5                  
Reclassification of warrants from liability to equity                     $ 213,000            
Common Stock [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Common stock issued for services (in shares)                     271,637            
Common stock issued for services                     $ 1,000            
Additional Paid-in Capital [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Common stock issued for services                     118,000            
Reclassification of warrants from liability to equity           $ 296,000         $ 213,000            
General and Administrative Expense [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Share-based compensation                   1,200,000              
Aggregate estimated granted warrants         $ 334,000         $ 334,000              
Amended and Restated Warrants [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Number of common stock to be purchased                   2,381,300              
Adjustment of warrants change in fair value increase additional paid in capital and accumulated loss                 $ 446,000                
Warrant excercise price                 $ 0.446                
Professional Relations and Consulting Service [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Warrants granted, term 5 years 5 years                              
Warrants granted to purchase common stock   250,000                              
Warrant expired date   2023-11                              
Warrant excercise price $ 0.47 $ 0.5                              
Professional Relations and Consulting Service [Member] | Maximum [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Warrants granted to purchase common stock 500,000                                
Restricted Stock [Member] | Professional Relations and Consulting Service [Member] | Common Stock [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Common stock issued for services (in shares)                 246,637                
Common stock issued for services                 $ 110,000                
2011 Stock Incentive Option Plan [Member] | Stock Options [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Vesting period                   3 years              
Exercisable/expiration period                   10 years              
Expiration date                   2021-05              
Stock option awards outstanding         1,728,773         1,728,773 4,412,940            
Number of shares authorized under the plan                                 9,000,000
2021 Stock Incentive Option Plan [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Total unrecognized compensation cost         $ 94,000         $ 94,000              
Options granted                   1,250,000              
Vesting period                   2 years              
Exercisable/expiration period                   10 years              
Stock option awards outstanding         1,250,000         1,250,000 0            
2021 Stock Incentive Option Plan [Member] | Stock Options [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Number of shares authorized under the plan                           4,000,000      
2011 and 2021 Stock Incentive Option Plan [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Share-based compensation                   $ 1,262,000 $ 16,000            
Stock option awards outstanding         3,223,881         3,223,881 4,660,787   5,968,338        
2011 and 2021 Stock Incentive Option Plan [Member] | Warrants Issued [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Share-based compensation                   $ 1,151,000              
2011 and 2021 Stock Incentive Option Plan [Member] | Stock Options [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Share-based compensation                   $ 111,000              
2012 Omnibus Incentive Compensation Plan [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Stock option awards outstanding         245,108         245,108 247,847            
Dr. Yutaka Niihara [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Change in fair value of warrants                     $ 14,000            
Employees [Member] | 2021 Stock Incentive Option Plan [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Options granted                   850,000              
Black-Scholes Merton model [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Warrant derivative liability                     70,000            
Non-Employee Director [Member] | 2021 Stock Incentive Option Plan [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Options granted                   300,000              
Vesting period                   1 year              
Consultant [Member] | 2021 Stock Incentive Option Plan [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Options granted                   100,000              
Employee Director [Member] | 2021 Stock Incentive Option Plan [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Vesting period                   3 years              
Convertible Promissory Note [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Adjustment of warrants change in fair value increase additional paid in capital and accumulated loss         $ 11,000   $ 41,000                    
Warrant excercise price         $ 0.29   $ 0.37     $ 0.29              
Convertible Promissory Note [Member] | Securities Purchase Agreement [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Convertible notes principal amount     $ 3,150,000                            
Convertible notes aggregate purchase price             $ 500,000         $ 1,000,000          
Change in fair value of warrant derivative liabilities                     1,300,000            
Extended maturity date     Jun. 15, 2023                            
Expected life (in years)     5 years                            
Number outstanding     1,250,000                            
Outstanding shares repayment     500,000                            
Percentage of monthly payments interest rate     12.00%                       2.00% 11.00%  
Warrant excercise price     $ 2.05                            
Repayment of debt     $ 0                            
Convertible Promissory Note [Member] | Maximum [Member] | Securities Purchase Agreement [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Convertible notes aggregate purchase price                             $ 17,000,000    
Senior Secured Convertible Promissory Note [Member] | GPB Debt Holdings II, LLC [Member] | Securities Purchase Agreement [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Convertible notes principal amount       $ 13,000,000                          
Convertible notes aggregate purchase price       $ 12,500,000                          
Original issue discount percentage       4.00%                          
Initial warrants exercisable period after issuance       5 years                          
Change in fair value of warrant derivative liabilities                     $ 40,000,000            
Warrant expiration date       2022-06                          
Warrants granted to purchase common stock       240,764                          
Warrant excercise price       $ 10.8