Annual report pursuant to Section 13 and 15(d)

STOCKHOLDERS' DEFICIT (Details Narrative)

v3.22.1
STOCKHOLDERS' DEFICIT (Details Narrative) - USD ($)
1 Months Ended 6 Months Ended 12 Months Ended
Feb. 26, 2021
Sep. 22, 2020
Jun. 15, 2020
Dec. 29, 2017
Mar. 31, 2021
Feb. 29, 2020
Oct. 31, 2018
Jul. 31, 2020
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2018
Sep. 29, 2021
Feb. 09, 2021
Jun. 29, 2020
Jan. 31, 2020
Jul. 17, 2019
Jul. 16, 2019
Class Of Warrant Or Right [Line Items]                                  
Convertible notes principal amount                 $ 18,007,000 $ 13,574,000              
Debt instrument exercise price   $ 2.00       $ 3.00                 $ 5.87    
Percentage of monthly payments interest rate           10.00%                      
Maturity date           Apr. 21, 2021                      
Conversion debentures price           $ 3.00                 $ 9.52    
Stock price                           $ 1.67      
Common stock purchase period   5 years                              
Loss on debt extinguishment, net                 $ 365,000 $ 1,425,000              
Common stock, issued                 49,311,864 48,987,189              
Share-based compensation                 $ 553,000 $ 739,000              
Period remaining for recognition of unrecognized compensation cost                 1 year 2 months 12 days                
Addition to equity for common stock                   142,000              
Research and development                 $ 4,110,000 $ 2,408,000              
Common Stock [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Common stock shares issued for consideration                   515,743              
Addition to equity for common stock                   $ 1,000              
2011 Stock Incentive Option Plan [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Exercise price - options                   $ 2.05              
Total unrecognized compensation cost                 $ 21,000                
2011 Stock Incentive Option Plan [Member] | Adjustment of Merger Exchange Ratio [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Exercisable term                 10 years                
2011 Stock Incentive Option Plan [Member] | Adjustment of Merger Exchange Ratio [Member] | Common Stock [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Stock options granted to purchase common stock                 0                
Exercise price - options                 $ 2.05                
2011 Stock Incentive Option Plan [Member] | Adjustment of Merger Exchange Ratio [Member] | Share Based Compensation Award, Tranche One [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Vesting period                 1 year                
Vesting percentage                 33.33%                
2011 Stock Incentive Option Plan [Member] | Adjustment of Merger Exchange Ratio [Member] | Share Based Compensation Award, Tranche Two [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Vesting period                 2 years                
Vesting percentage                 66.67%                
2011 Stock Incentive Option Plan [Member] | Stock Options [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Number of shares authorized under the plan                     9,000,000            
Expiration period                 10 years                
Vesting period                 3 years                
Share-based compensation                 $ 553,000 $ 739,000              
2021 Stock Incentive Option Plan [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Common stock, issued                       4,000,000          
Kainos Medicine, Inc [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Payments to research and development expense $ 500,000                                
Common stock shares issued for consideration 324,675                                
Addition to equity for common stock $ 500,000                                
Research and development                 $ 1,500,000                
Amended and Restated Warrants [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Debt instrument exercise price         $ 1.54 2.00                   $ 5.87  
Amended Previous Issued Warrant [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Debt face amount percentage                 1,365,189                
Debt instrument exercise price                 $ 4.76                
Securities Amendment Agreement [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Maturity date   Aug. 31, 2021           Apr. 21, 2021                  
Monthly redemption payment on principal amount   $ 500,000,000           $ 1,000,000,000                  
Monthly redemptions description                 Pursuant to the Allonge, the aggregate monthly redemption payments under the Debentures were reduced to $500,000 from $1,000,000 in principal amount and the maturity date of the Debentures was extended from April 21, 2021 to August 31, 2021. The monthly redemption payments resumed in September 2020.                
Convertible Bond Purchase Agreement [Member] | T.R. Winston & Company, LLC [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Debt instrument exercise price                     $ 2.10            
Maximum [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Number of common stock to be purchased   1,840,000                              
Maximum [Member] | 2011 Stock Incentive Option Plan [Member] | Adjustment of Merger Exchange Ratio [Member] | Common Stock [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Stock options granted to purchase common stock                   90,000              
Maximum [Member] | Convertible Bond Purchase Agreement [Member] | T.R. Winston & Company, LLC [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Number of common stock to be purchased                     75,000            
Amended and Restated Debentures [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Debt instrument exercise price           2.00                      
Conversion debentures price           $ 2.00                      
Initial shares under purchase agreement           100,000                      
Stock price           $ 2.00                      
10% Secured Senior Debentures [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Percentage of monthly payments interest rate         10.00%       10.00%                
Loss on debt extinguishment, net         $ 1,200,000                        
Convertible Promissory Note [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Stock price                 $ 1.67 $ 1.68              
Number outstanding                 1,250,000 1,250,000              
Convertible Promissory Note [Member] | Securities Purchase Agreement [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Convertible notes principal amount     $ 3,150,000                            
Debt instrument exercise price     $ 2.05                            
Percentage of monthly payments interest rate     12.00%             11.00%     2.00%        
Conversion price                         $ 1.48        
Extended maturity date     Jun. 15, 2023                            
Number outstanding     1,250,000                            
Loss on debt extinguishment, net     $ 1,400,000                            
Expected life (in years)     5 years                            
Convertible Promissory Note [Member] | Maximum [Member] | Securities Purchase Agreement [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Convertible notes aggregate purchase price                         $ 17,000,000        
Senior Secured Convertible Debentures [Member] | Securities Purchase Agreement [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Percentage of monthly payments interest rate                 10.00%                
Senior Secured Convertible Debentures [Member] | Amended and Restated Debentures [Member] | Securities Amendment Agreement [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Percentage of monthly payments interest rate   10.00%                              
GPB Debt Holdings II, LLC [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Percentage of monthly payments interest rate                                 10.00%
GPB Debt Holdings II, LLC [Member] | Amended and Restated Warrants [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Debt instrument exercise price                                 $ 10.00
GPB Debt Holdings II, LLC [Member] | Maximum [Member] | Amended and Restated Warrants [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Debt face amount percentage                                 1,460,000
GPB Debt Holdings II, LLC [Member] | Senior Secured Convertible Promissory Note [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Debt face amount percentage       240,764                          
Debt instrument exercise price       $ 10.80                          
Initial warrants exercisable period after issuance       5 years                          
GPB Debt Holdings II, LLC [Member] | Purchase Agreement With 10% Senior Secured Debentures [Member] | Securities Purchase Agreement [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Percentage of monthly payments interest rate             10.00%                    
Principal amount of debentures and warrants issued             $ 12,200,000                    
Debenture and warrants issued to original loan             $ 13,200,000                    
GPB Debt Holdings II, LLC [Member] | Purchase Agreement With 10% Senior Secured Debentures [Member] | Maximum [Member] | Securities Purchase Agreement [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Number of common stock to be purchased             1,220,000                    
GPB Debt Holdings II, LLC [Member] | Amended and Restated Debentures [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Conversion price                                 $ 10.00
GPB Debt Holdings II, LLC [Member] | Convertible Debt [Member] | Senior Secured Convertible Promissory Note [Member]                                  
Class Of Warrant Or Right [Line Items]                                  
Convertible notes principal amount       $ 13,000,000                          
Convertible notes aggregate purchase price       $ 12,500,000                          
Original issue discount percentage       4.00%