Annual report pursuant to Section 13 and 15(d)

STOCKHOLDERS' DEFICIT (Details Narrative)

v3.23.1
STOCKHOLDERS' DEFICIT (Details Narrative) - USD ($)
1 Months Ended 6 Months Ended 12 Months Ended
Feb. 26, 2021
Jun. 15, 2020
Sep. 30, 2022
Jun. 30, 2022
Jun. 30, 2022
Dec. 31, 2022
Dec. 31, 2021
Jun. 15, 2022
Sep. 29, 2021
Feb. 09, 2021
Dec. 31, 2020
Dec. 31, 2018
Oct. 31, 2018
Class Of Warrant Or Right [Line Items]                          
Convertible notes principal amount           $ 27,562,000 $ 18,007,000            
Percentage of monthly payments interest rate                         1.00%
Loss on debt extinguishment           $ 501,000 $ 365,000            
Common stock, issued           49,583,501 49,311,864            
Warrant derivative liabilities           $ 70,000 $ 1,503,000            
Change in fair value of warrant derivative liabilities           $ 1,304,000 (432,000)            
Average remaining contractual terms for warrants           2 years 1 month 6 days              
Share-based compensation           $ 16,000 553,000            
Research and development           1,725,000 4,110,000            
Adjustment of warrants change in fair value increase additional paid in capital and accumulated loss         $ 446,000                
Common stock issued for services           $ 119,000 $ 500,000            
Common Stock [Member]                          
Class Of Warrant Or Right [Line Items]                          
Common stock issued for services (in shares)           271,637 324,675            
Common stock issued for services           $ 1,000              
Stock Options [Member]                          
Class Of Warrant Or Right [Line Items]                          
Period remaining for recognition of unrecognized compensation cost           6 months              
2011 Stock Incentive Option Plan [Member]                          
Class Of Warrant Or Right [Line Items]                          
Total unrecognized compensation cost           $ 5,000              
2011 Stock Incentive Option Plan [Member] | Stock Options [Member]                          
Class Of Warrant Or Right [Line Items]                          
Number of shares authorized under the plan                       9,000,000  
Expiration period           10 years              
Vesting period           3 years              
Share-based compensation           $ 16,000 $ 553,000            
2021 Stock Incentive Option Plan [Member]                          
Class Of Warrant Or Right [Line Items]                          
Common stock, issued                 4,000,000        
Kainos Medicine, Inc [Member]                          
Class Of Warrant Or Right [Line Items]                          
Payments to research and development expense $ 500,000                        
Common stock shares issued for consideration 324,675                        
Addition to equity for common stock $ 500,000                        
Research and development           $ 0 $ 1,500,000            
Amended and Restated Warrants [Member]                          
Class Of Warrant Or Right [Line Items]                          
Debt instrument exercise price       $ 0.446 $ 0.446                
Number of common stock to be purchased           4,038,200              
Professional Relations and Consulting Service [Member] | Restricted Stock [Member] | Common Stock [Member]                          
Class Of Warrant Or Right [Line Items]                          
Common stock issued for services (in shares)       246,637   25,000              
Common stock issued for services       $ 110,000   $ 9,000              
Dr. Yutaka Niihara [Member]                          
Class Of Warrant Or Right [Line Items]                          
Warrants granted to purchase common stock     500,000                    
Debt instrument exercise price     $ 2.50                    
Warrants granted, term     5 years                    
Warrant derivative liabilities           70,000              
Change in fair value of warrant derivative liabilities           $ 14,000              
Convertible Promissory Note [Member]                          
Class Of Warrant Or Right [Line Items]                          
Number outstanding             1,250,000 1,250,000          
Convertible Promissory Note [Member] | Securities Purchase Agreement [Member]                          
Class Of Warrant Or Right [Line Items]                          
Convertible notes principal amount   $ 3,150,000                      
Debt instrument exercise price   $ 2.05                      
Percentage of monthly payments interest rate   12.00%               2.00% 11.00%    
Extended maturity date   Jun. 15, 2023                      
Number outstanding   1,250,000                      
Loss on debt extinguishment   $ 1,400,000                      
Repayment of debt   $ 0                      
Expected life (in years)   5 years