EXHIBIT 32.1


                            CERTIFICATION PURSUANT TO
                             18 U.S.C. SECTION 1350
                             AS ADOPTED PURSUANT TO
                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002



         Pursuant to 18 U.S.C.  Section 1350, as adopted pursuant to Section 906
of the  Sarbanes-Oxley  Act of  2002,  in  connection  with  the  filing  of the
Quarterly  Report on Form 10-Q for the  quarter  ended  December  31,  2008 (the
"Report") by CNS  Response,  Inc. (the  "Registrant"),  the  undersigned  hereby
certifies that to the best of his knowledge:

         1.       the Report fully  complies  with the  requirements  of section
                  13(a) or 15(d) of the Securities Exchange Act of 1934; and

         2.       the information  contained in the Report fairly  presents,  in
                  all material respects,  the financial condition and results of
                  operations of the Registrant.



Date:  February 17, 2009                /s/ Leonard J. Brandt
                                        ----------------------------------
                                        Leonard J. Brandt
                                        Chief Executive Officer (Principal
                                        Executive and Financial Officer)