EXHIBIT 32.1 CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002 Pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, in connection with the filing of the Annual Report on Form 10-K for the year ended September 30, 2008 (the "Report") by CNS Response, Inc. (the "Registrant"), the undersigned hereby certifies that: 1. the Report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934; and 2. the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Registrant. Date: January 13, 2009 /S/ LEONARD BRANDT --------------------------------- Leonard J. Brandt Chief Executive Officer (Principal Executive and Financial Officer)